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What Clomipramine is used for Clomipramine is used to treat depression (especially if you also need to be sedated), obsessions and phobias (irrational fears). It is also used along with other medications to treat cataplexy. Do not use Clomipramine • are allergic to clomipramine or any of the other ingredients of this medicine • have ever had a rash or other allergic reaction to any other antidepressants • have had a heart attack within the last 3 months • have problems with your heart beat • have any serious liver disease • have a mental health condition called mania • have glaucoma (increased eye pressure) • have difficulty in passing urine • are taking, or within the last 3 weeks have taken medicines for depression called monoamine oxidase inhibitors (MAOI) • are taking medicines called selective, reversible monoamine oxidase-A (MAO-A) inhibitors such as moclobemide Warnings and precautions Talk to your doctor or pharmacist before taking Clomipramine if you: • have ever had suicidal thoughts • suffer from epilepsy (fits) • have had a head injury or have suffered brain damage • are going to have electric shock therapy (ECT) • have other problems with your heart • have been told you have a low level of potassium in your blood (hypokalemia) • have kidney disease • suffer from schizophrenia or other mental health conditions • have a blood disorder • have an overactive thyroid gland • have had severe constipation for a long time • have a tumor (cancer) of the adrenal gland (such as phaeochromocytoma or neuroblastoma) • liver disease • have low blood pressure • wear contact lenses • are elderly Possible side effects Stop using the product and seek immediate medical attention if you develop throat tightness or swelling of the eyes, face, lips or tongue, feel faint, or have difficulty breathing. Stop using the product if you develop hives or itching of the face or body. Other medicines and Clomipramine Clomipramine interacts with a large number of other medicines. Make sure your doctor or pharmacist knows if you are taking any of the following: • medicines for depression, particularly MAOIs • diuretics • anesthetics • antihistamines • medicines for other mental health conditions such as schizophrenia or manic depression • medicines for high blood pressure e.g. guanethidine, betanidine, reserpine, clonidine or alpha • methyldopa or norepinephrine • norepinephrine (noradrenaline) • medicines to treat heart disorders • beta-blockers • anticoagulants • aspirin and similar pain killing non-steroidal anti-inflammatory drugs (NSAIDs) • medicines for Parkinson's Disease • nicotine • anticonvulsants • decongestants • cimetidine • methylphenidate • rifampicin • quinine • strong painkillers such as tramadol, nefopam, morphine or morphine related substances • drugs of abuse including Ecstasy • atropine or similar medicines • medicines containing estrogens • medicines called protease inhibitors, used to treat Human Immunodeficiency Virus (HIV) • terbinafine • colestipol, cholestyramine • St. John’s wort (Hypericum perforatum) • disulfiram • altretamine • baclofen • pentamidine • levacetylmethadol How to use Clomipramine The recommended dose is: • For depression a starting dose of 10 mg which can be increased to find a dose that works for you. This is normally 30 - 150 mg daily or up to a maximum of 250 mg daily for severe conditions. • For obsessions and phobias, a starting dose of 25 mg which can be increased to 100 - 150 mg daily. • For cataplexy a starting dose of 10 mg which can be increased to a maximum of 75 mg daily. How to store Clomipramine Store Clomipramine capsules below 25°C in a dry place. Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date, which is stated on the pack or bottle. The expiry date refers to the last day of that month. Do not throw away any medicines via wastewater or household waste.